Scientists managed to eradicate cancer using non-invasive sound waves. Namely, ultrasound pulses high amplitude to partially destroy liver tumors in rats.
What activates the immune system of rodents to eliminate the cancer cells remaining and prevent the disease from spreading or coming back.
Researchers say their technique could lead to effective treatments
Presenting their findings in the journal Cancers the researchers behind this breakthrough say their technique could lead to effective treatments. And non-invasive for some of the most intractable cancers in human patients.
The Liver cancer it certainly falls into that category and is associated with a five-year survival rate of only 18 percent in the US Although there are plenty of options for treatment availableliver tumors tend to metastasize or recur after these interventions.
In their study, the scientists explain that treatments Conventional treatments for cancer, such as chemotherapy, radiotherapy and thermal ablation. They are effective in destroying tumors. But they also trigger immune reaction somewhat unpredictable that can be antitumor or protumoral. In addition, they point out that the size, location and stage of a tumor can sometimes make it impossible to target the entire mass of tissue with existing treatments.
To replicate these complexities clinical trials, the scientists decided to destroy only a part of each cancer tumor. Leaving a viable portion in the livers of animals.
ABOUT THE STUDY
They began by inoculating 22 rats with cancer cells liver and allowing these tumors to develop for up to nine days. Reaching a size of 5 to 10 millimeters (0.2 to 0.4 inches).
At this point, half of the rats were treated with a technique called history. Which consists of attacking the tumors with millisecond-long pulses of high-amplitude ultrasound waves.
This creates an effect known as ultrasound cavitation, whereby small bubbles develop and burst within the target tissue. What causes the destruction of cancer cells. Meanwhile, the traditional devices Ultrasound imaging uses smaller amplitude pulses to avoid causing damage.
RESULTS
Although only 50 to 75 percent of each tumor mass with history. The researchers noted that nine of the 11 treated rats showed a full local regression of the tumour. No signs of recurrence of metastases during the remainder of the 12-week study period.
In the days after treatment, the team detected an increase in cells anticancer immune cells, such as T cells and natural killer cells within the tumor microenvironment. This indicates that histotricia can stimulate the immune system of animals to destroy the remaining cancer and prevent its spread. or return
In contrast, the 11 untreated control rats experienced a tumor progression and they had to be euthanized within three weeks of the start of the study.
Currently carrying out a clinical trial with human subjects with liver cancer and is expected to end in the middle of next year. Any replication of these preclinical results would represent a breakthrough in the battle against cancer.
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