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According to Statista, The global market for cell and gene therapy manufacturing is projected to quadruple by 2030.
The total global stem cell therapy market was valued at about $755 million in 2018.
According to Statista, It is estimated that the global stem cell market will increase to 15.6 billion dollars in 2025.
A protein known as platelet-derived growth factor B subunit (PDGF-B), which is continuously released by skeletal muscle cells, has been found to aid muscle repair by promoting the formation of myoblasts, or muscle stem cells, according to a study. research from Tokyo Metropolitan University.
They discovered that the PDGF-B protein also promotes the growth of muscle fibers. According to the researchers, this corresponds to a greater contraction of the fibers. The drugs discovered could revolutionize the treatment of muscle atrophies and injuries.
According to the study, myokines are small proteins secreted by skeletal muscle cells. They have a wide range of functions and can act on cells near and far from where they are produced.
It is not yet clear how myokines affect cellular processes, but they are thought to play an important role in exercise-related bodily functions, particularly the maintenance of muscle tissue.
The team led by Associate Professor Yasuko Manabe, from Tokyo Metropolitan University, has studied how myokines affect the behavior of muscle cells. Through extensive experiments, they discovered that a myokine known as platelet-derived growth factor B subunit, or PDGF-B, is secreted by skeletal muscles constitutively, that is, without any stimulus.
To find out what role it plays, they took myoblasts, precursor cells that differentiate into muscle fibers, and exposed them to PDGF-B. Thus, they were able to clearly demonstrate that PDGF-B is a platelet-derived growth factor, clearly demonstrating that PDGF-B induced increased myoblast proliferation.
Interestingly, they also found that PDGF-B affected cells that had already differentiated. They took myotubes, a developmental stage of muscle fibers, and exposed them to the same myokine. Myotubes treated in this way showed significantly greater maturation, visibly increasing their diameter under microscopic observation.
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