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According to Statista, during 2019 there were 23,337 deaths due to leukemia in the United States.
According to the Ministry of Health, 50% of the new cases registered in children under 18 years of age in Mexico are due to leukemia.
According to Statista, The leukemia death rate in the United States during 2019 was 5.9 per 100,000 inhabitants.
A patient under 13 years of age from the United Kingdom who had been given up 6 months ago due to leukemia received an experimental treatment by the team of the doctor at the Great Ormond Street Hospital for Children in London (GOSH for its acronym in English). ) that saved his life.
According to an official statement from the GOSH, Alyssa was diagnosed with T-cell acute lymphoblastic leukemia in the year 2021. He received all current conventional therapies to treat his cancer, including chemotherapy and a bone marrow transplant. Unfortunately, her illness returned and no further treatment options were available as part of routine care.
So she was considered to enroll as a patient for a new clinical trial. In May, he was admitted to the Bone Marrow Transplantation (BMT) Unit at GOSH, to receive genetically modified CAR T cells that originally came from a healthy donor.
What is the experimental treatment that saved the life of the minor with Leukemia?
Medical teams at the hospital have been using a genome editing technique called base editing, a method of chemical conversion of the DNA code to change T cells, which are white blood cells that are a critical part of the immune system.
According to the statement, these cells have been edited using a new base editing technology to allow them to hunt down and kill cancer T cells without attacking each other.
“It is our most sophisticated cell engineering yet, and it paves the way for other new treatments and ultimately better futures for sick children,” said Waseem Qasim, professor of cell and gene therapy at GOSH.
6 months ago, after all other treatments for T-cell acute lymphoblastic leukemia had failed, Alyssa became the first person in the world to receive base-edited cell therapy as part of a clinical trial at GOSH & @UCLchildhealth. Meet Alyssa & the research team behind the trial 👇 pic.twitter.com/YwCQfnCJux
—Great Ormond Street Hospital (@GreatOrmondSt) December 11, 2022
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