Of all the things that COVID confused us about, one thing we were particularly clear about was that it is a respiratory illness.
A University of San Diego study claims to have proof that COVID-19 is not a respiratory disease, but a vascular one.
What is it about?
The article, published in Circulation Research, it also shows conclusively that COVID-19 is a vascular disease. Which shows exactly how the SARS-CoV-2 virus damages and attacks the vascular system at the cellular level.
This could explain blood clots in some COVID patients and other problems like “COVID feet.” Which are not classic symptoms of a respiratory disease.
Vascular disease: new doors to the COVID-19 virus
Moreover, the findings help explain the wide variety of seemingly unrelated complications of COVID-19. Just as they could open the door to new research on more effective therapies.
In fact, the majority of patients infected with the COVID-19 virus reported mild to moderate respiratory symptoms. But they recovered without any professional care.
This is how the virus affects the arterial or circulatory system
The new study claims that COVID-19 is a vascular condition and not a lung disease, as is often assumed. According to experts, blood clots in some COVID patients. As well as other concerns such as ‘COVID feet’, it is generally not an indicator of a respiratory problem.
According to research, the virus targets the arterial or circulatory system. Its protein S, which forms the crown, attacks the ACE2 receptor and damages the cell’s mitochondria. Which generates energy and, consequently, the endothelium, which covers the blood artery.
ABOUT THE STUDY:
The research formulated a pseudovirus that only included protein S and no other part of the virus to demonstrate in the laboratory that this protein is sufficient to induce disease on its own. This has already been seen, but the exact method and function of protein S was unknown until now. According to the study, this protein is recreated by all currently known vaccines.
“A lot of people think it’s a respiratory disease, but it’s actually a vascular disease,” says research assistant professor Uri Manor, a co-lead author of the study. “That could explain why some people have strokes and why some people have problems in other parts of the body. The common point between them is that they all have vascular bases ”.
Vascular endothelial cells
The Salk researchers collaborated with scientists at the University of California, San Diego on the paper, including co-author Jiao Zhang and co-lead author John Shyy, among others.
While the findings themselves are not entirely a surprise. The paper provides clear confirmation and detailed explanation of the mechanism through which the protein damages vascular cells for the first time.
There has been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damage to vascular endothelial cells. But this is the first time the process has been documented.
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