- For the study, blood samples were collected from 20 healthy children at the Royal Children’s Hospital in Melbourne.
- The researchers discovered the blood clotting pathways and immune proteins that are activated in severe cases of Covid-19 in children.
- Specimen collection are key issues to improve treatment and outcomes.
Researchers in Australia have discovered the pathways of coagulation blood and immune proteins that are activated in severe cases of Covid-19 In the kids. This allows a quick diagnosis and more specific treatments, reported this Monday, May 2, the magazine “Nature Communications”.
Mechanisms of disease identified in children with Covid-19
The study, led by Murdoch Children’s Research Institute (MCRI) and the University of Melbourne. identified disease mechanisms in children with Covid-19 who have multisystem inflammatory syndrome, where different parts of the body can become inflamed, including the heart.
“Children are, in general, less susceptible to COVID-19 and have milder symptoms, but it is not clear what causes some to develop very severe illness,” said MCRI researcher Conor McCafferty.
“Our research was the first to uncover the specific blood coagulation pathways and affected immune proteins in children with COVID-19 who developed severe symptoms,” he added.
Blood samples were collected from 20 healthy children at the Royal Children’s Hospital in Melbourne.
For the study, samples were collected from blood from 20 healthy children in it Royal Children’s Hospital Melbourne and samples from 33 SARS-CoV-2 infected children with multisystem inflammatory syndrome or acute respiratory distress syndrome from Necker-Enfants Malades Hospital, in Paris.
Professor Damien Bonnet, from the Hospital Necker-Enfants Malades, considered that the collection of samples are key issues to improve treatment and results.
The research found that 85 proteins were specific to multisystem inflammatory syndrome and 52 proteins to acute respiratory distress syndrome.
The discoveries were made possible with the help of an experimental approach
McCafferty said the discoveries were made possible with the help of an experimental approach that allowed experts to investigate almost 500 proteins that circulate in the blood at the same time.
Children with coronavirus who have multisystem inflammatory syndrome have fever, abdominal pain, vomiting, rash, and conjunctivitis. This makes it difficult to quickly diagnose patients, the study indicates.
The expert Vera Ignjatovic, from MCRI, considered that the results help to understand the severe cases of Covid-19 in childrenwhich would help in the development of diagnostic tests for the rapid identification of minors at risk.
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