Omeprazole consumption causes profound erectile dysfunction in healthy young man

Omeprazole consumption causes profound erectile dysfunction in healthy young man
  • The case presented in a 38-year-old Caucasian man with mild hypertension and no other significant medical history.
  • The man developed profound erectile dysfunction within 2 days of starting nonprescription omeprazole therapy.
  • At the time of the episode, the patient was taking a stable dose of lisinopril and was not taking any other medications or supplements.

The case was filed in a caucasian man A 38-year-old woman with mild hypertension and no other significant medical history developed a dysfunction erectile dysfunction within 2 days of starting nonprescription omeprazole therapy.

At the time of the episode, the patient was taking a stable dose of lisinopril and was not taking any other medications or supplements.

OMEPRAZOLE

Omeprazole is an antacid medication. Specifically, it is a proton pump inhibitor (it is the mechanism by which cells secrete acid). to decrease stomach acid secretion.

Omeprazole was developed by the Swedish company Aktiebolaget Hässle. This company began in 1966 to investigate proton pump inhibitors (PPIs). After testing various compounds chemically related to lidocainein 1979 they developed omeprazole.

They found that it inhibited acid secretion against all agonists, that is, against all those substances that increased this secretion, not just histamine. But omeprazole is a compound that breaks down easilyespecially in acid medium. So further investigation was necessary. In 1987 the Astra company developed and patented a stable oral pharmaceutical formulation.

It is made up of a nucleus containing a alkaline salt of omeprazole (magnesium salt, for example) and a coating of one or more layers containing excipients (substances that are not drugs, are not active in our body)

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MEDICAL CASE: Omeprazole consumption causes profound erectile dysfunction in a healthy young man

Several factors in this patient’s clinical history make a convincing argument implicating omeprazole as a potent precipitant for dysfunction erectile. These include the temporal relationship of the start of dysfunction erectile dysfunction with initiation of omeprazole therapy, prompt resolution of symptoms after drug discontinuation, absence of other readily apparent precipitating factors, and absence of recurrent erectile dysfunction in the 2 years after the episode.

According to the doctors, the 38-year-old patient began to have symptoms of erectile dysfunction once he began his omeprazole therapy. However, when the clinical team decided to discontinue the medication, his symptoms disappeared and even he was able to recover and also during the two subsequent years he did not present the pathology, even using the medication.

The authors of this case insisted that the use of this drug should be considered as a potential cause of erectile dysfunction in young and healthy patients, as well as in older patients. On the other hand, they emphasized that more studies are needed to verify that erectile diffusion can appear as an effect of this drug.

Finally, the indecency of this type of clinical scenario attributed to this type of therapy is little recognized in the literature, so more scientific studies are urged and the use of these drugs should be reconsidered in young patients.

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