Something we don’t think about when an organ transplant is done is that they can have a surprisingly long life if we add the time they were in the donor and the time they survive with the recipient. In the case of livers, it has been seen that in some cases this added age can exceed 100 years. It is the conclusion of a recently presented investigation in the Scientific Forum of the 2022 Clinical Congress of the American College of Surgeons (ACS). In it, the factors that converge in what its authors have baptized as centurion organs.
In general, a series of factors coincide, both from the donor and the recipient, which make it easier for the organ to be able to survive much longer than the donor possibly would have survived under other circumstances. And knowing this is essential, as it can help you choose the best livers for your transplant. After all, the longer their survival, the better the recipient’s quality of life.
It is true that the newer immunosuppression techniques they increase much more the time of life of the organs for its transplantation. However, the centurion livers can give us interesting data to increase that time even more. Let’s see what these scientists of the UT Southwestern School of Medicine.
The keys to centurion liver transplantation
To carry out your studythese scientists analyzed 253,406 livers transplanted between 1990 and 2022. Of all of them, 24 could be classified as centurion livers.
the best donors
The first thing that stands out is that the centurion liver donors had on average 87.5 years. On the one hand, it makes sense, since they had traveled with the donor for a good part of that century that makes them centurions. However, it is also curious, since it could be considered that they are poor quality organs. In fact, those of older people are often considered less suitable. Of course, although they were older, the donors were especially healthy, since they had an incidence of diabetes and infections much lower than that of non-centurion livers. In addition, they also play a key role transaminaseswhich were much lower among centurion liver donors.
Transaminases are very important proteins in the metabolism of cells of different organs, including the liver. However, if they are elevated they can be indicative of health problemsHence, it is not surprising that livers with lower levels survive longer after transplantation.
the best receivers
As for the recipients, it was seen that those who received a centurion organ had MELD scores much lower. This is an index of the survival of people with liver disease and is measured through the analysis of three parameters: bilirubin, serum creatinine, and international normalized ratio of prothrombin time (INR). The lower the index, the better the prognosis.
Therefore, if both donors and recipients are optimal, much longer organ survival can be achieved. However, it is important to note that this is long-term information. No differences were observed in 12-month transplant rejection rates with centurion or non-centurion livers. It was later that the advantages of matching a donor in good health with a recipient who, despite needing to receive an organ, had a better prognosis were observed. Not a surprise, actually. What is surprising is that, since it is very difficult for a human being to exceed 100 years, his organs separately can pass the century with relative ease.