- Dr. Erandi Escamilla García and her research group received a patent to create an edible gelatin that fights dental caries in children.
- The study body was a group of 27 children between six and seven years of age. They evaluated the amount of cavities in their dentures.
- This line of research was born in 2014 in the Master’s thesis in Pediatric Dentistry of the Faculty of Dentistry.
According to the UANL, After almost 10 years of studies with molecules with antimicrobial capacities, Dr. Erandi Escamilla García and her research group received a patent to create an edible gelatin that combat tooth decay in children.
This line of research was born in 2014
The doctor coordinated a group of researchers from the Microbial Biotechnology Laboratory of the Center for Research and Development in Health Sciences (CIDICS-UANL) who worked with the 3-hydroxypropionaldehyde molecule, from reuterin.
The Mexican Institute of Industrial Property (IMPI) granted in December 2021 the patent: “Process of obtaining a gelled food against dental caries supplemented with reuterin partially purified from Lactobacillus reuteri”.
This line of research was born in 2014 in the thesis of Master’s Degree in Pediatric Dentistry from the Faculty of Dentistry, defended by the dental surgeon Magda Lorena Baca Castañón, a native of Chihuahua and who returned to her hometown.
In addition to doctors Erandi Escamilla and Magda Baca, Dr. Andrea Guadalupe Alcázar Pizaña participated in the investigation.Dr. Juan Carlos Segoviano Ramírez, and fellow dentist Ada Priscila López Lozano.
Fight infant cavities
Since she arrived at the Microbial Biotechnology Laboratory, Dr. Escamilla García became interested in isolating and characterizing bacteriaespecially molecules that could have some biological potential for clinical use.
The student Victor Hugo Urrutia participated in the project with his master’s thesis by studying the biological potential of reuterin on the growth of the bacterium helicobacter pylori and the inhibition in the expression of virulence genes.
The body of study was a group of 27 children between six and seven years of age. They evaluated the amount of cavities in their dentures. In the laboratory, in vitro and murine (mice) studies had given reuterin good results against S. mutans of caries.
“We managed to demonstrate that the molecule isolated from its biological niche has the ability to reduce the cariogenic pathogen [S. mutans] present in children. And to make it more attractive to children, instead of making a pill we made a jelly.”
To the group of children they applied a placebo, the pathogen disappeared by 87.2 percent, but reappeared after a few minutes. To the group that applied the active ingredient in gelatin, the colonies of S. Mutans disappeared by 99.86 percent with reuterin.
Teamwork that paid off
From her native Chihuahua, Magda Baca told Vida Universitaria that what began with the development of her thesis little by little became a line of research in which researchers from CIDICS and the School of Dentistry worked.
They create gelatin against dental diseases
Baca Castañón stressed that He is not aware of a line of research similar to the one headed by Dr. Erandi Escamilla. Perhaps it is because most of the laboratories work directly with bacteria and they at CIDICS do so with molecules with potential.
Such is the case that the laboratory has collaborations with researchers from the Faculties of Biological Sciences, Chemical Sciences, and the local unit of Cinvestav. His plan is to open doors with other centers with experience and infrastructure.
“The idea is that the Microbial Biotechnology Laboratory generates its own molecules of natural origin that we can characterize for preventive or therapeutic purposes, which are alternatives at the biomedical level.”
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